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Original Research
Online Published: 27 Dec 2022
 


Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment

Johan Gomar Gama, Djonny Ferianto Pualillin, Salman Ardi Syamsu, Indra, Daniel Sampepajung.


Abstract
Introduction: VEGF A has an important role in the vascular developmental process. VEGF A level increase in breast cancer and associated with higher rate of recurrence and mortality.
Methods: It is an observational cross-sectional study. The VEGF A levels are measured using ELISA.
Results: There is a significant difference between the size of tumor before and after administration of Neoadjuvant TAC chemotherapy: 29 (72.5%) responsive: 11 (27.5%) unresponsive, P= 0,000 (P value <0.05). 25 (62.5%) patients have decreased VEGF A level and 15 (37.5%) patients have the same or increased level of serum. Statistical analysis showed P value = 0.468 (P>0,05) which means that there is no significant difference between VEGF A before and after chemotherapy. There is an association between VEGF A level and clinical response of neoadjuvant TAC chemotherapy P = 0,037 (P value < 0,05).
Conclusion: There is a significant positive outcome in clinical response of breast cancer patients on neoadjuvant TAC chemotherapy. Decrease level of VEGF A is lower after TAC chemotherapy but not statistically significant. There is an association between VEGF A level with clinical response after neoadjuvant TAC chemotherapy in breast cancer patients.

Key words: VEGF A, breast cancer, neoadjuvant TAC chemotherapy


 
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How to Cite this Article
Pubmed Style

Gama JG, Pualillin DF, Syamsu SA, Indra , Sampepajung D. Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. Int J Med Rev Case Rep. 2022; 6(24): 19-23. doi:10.5455/IJMRCR.172-1650784590

Web Style

Gama JG, Pualillin DF, Syamsu SA, Indra , Sampepajung D. Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. https://www.mdpub.net/?mno=25655 [Access: October 13, 2024]. doi:10.5455/IJMRCR.172-1650784590

AMA (American Medical Association) Style

Gama JG, Pualillin DF, Syamsu SA, Indra , Sampepajung D. Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. Int J Med Rev Case Rep. 2022; 6(24): 19-23. doi:10.5455/IJMRCR.172-1650784590


Vancouver/ICMJE Style

Gama JG, Pualillin DF, Syamsu SA, Indra , Sampepajung D. Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. Int J Med Rev Case Rep. (2022), [cited October 13, 2024]; 6(24): 19-23. doi:10.5455/IJMRCR.172-1650784590


Harvard Style

Gama, J. G., Pualillin, . D. F., Syamsu, . S. A., Indra, . & Sampepajung, . D. (2022) Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. Int J Med Rev Case Rep, 6 (24), 19-23. doi:10.5455/IJMRCR.172-1650784590


Turabian Style

Gama, Johan Gomar, Djonny Ferianto Pualillin, Salman Ardi Syamsu, Indra, and Daniel Sampepajung. 2022. Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. International Journal of Medical Reviews and Case Reports, 6 (24), 19-23. doi:10.5455/IJMRCR.172-1650784590


Chicago Style

Gama, Johan Gomar, Djonny Ferianto Pualillin, Salman Ardi Syamsu, Indra, and Daniel Sampepajung. "Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment." International Journal of Medical Reviews and Case Reports 6 (2022), 19-23. doi:10.5455/IJMRCR.172-1650784590


MLA (The Modern Language Association) Style

Gama, Johan Gomar, Djonny Ferianto Pualillin, Salman Ardi Syamsu, Indra, and Daniel Sampepajung. "Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment." International Journal of Medical Reviews and Case Reports 6.24 (2022), 19-23. Print. doi:10.5455/IJMRCR.172-1650784590


APA (American Psychological Association) Style

Gama, J. G., Pualillin, . D. F., Syamsu, . S. A., Indra, . & Sampepajung, . D. (2022) Correlations between vascular endothelial growth factor-A (VEGF-A) levels and clinical response of locally advanced breast cancer stadium and metastases treating neoadjuvant chemotherapy taxan anthracycline cyclophosphamide (TAC) regiment. International Journal of Medical Reviews and Case Reports, 6 (24), 19-23. doi:10.5455/IJMRCR.172-1650784590


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