E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 11
7 / 11Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Case Report
Online Published: 15 May 2019
 


Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury

Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Pooja Kulkarni, Suhasini Pai, Khushboo Bhagwanani, Nayana Shet, Samson Nivins, Prerna Badhe.


Abstract
Introduction: Positron Emission Tomography (PET) imaging provides exquisite sensitivity information regarding changes in brain metabolism after traumatic brain injury (TBI). TBI is major cause of morbidity and mortality resulting in permanent neurobiological damage and lifelong deficits. Cell transplantation in combination with neurorehabilitation has a potential to cease the degeneration and replace the damaged neurons, which current standard intervention may not tackle.
Methods: Herein, we present a case of a 7-year-old female who suffered from TBI 15 months before she underwent first cell transplantation. She underwent two cell transplantations at an interval of 4 months with intrathecal autologous bone marrow derived mononuclear cells.
Results: Over the span of 9 months, improvements in posture, balance, bed mobility, voluntary control of the upper extremity, overhead activities, cognition, speech, understanding and attention was observed. Percutaneous endoscopic gastrostomy (PEG) tube was removed as her swallowing capacity improved. The Functional independence measure (FIM) score improved from 22 to 35 and Disability rating scale (DRS) improved from 15 to 12. There was an improvement in the Glasgow coma scale from 8 to 15. A repeat PET CT scan of the brain at 4 months’ post first cellular transplantation revealed improved metabolism in the cerebellum, cingulate regions, vermis and parietal gyrus. These changes corresponded to the clinical improvements seen in the patient. No adverse events related to the procedure was observed.
Conclusion: Cell transplantation is a safe and efficacious treatment for chronic TBI. However, we recommend future controlled clinical trials with objective imaging like PET CT to further establish cell transplantation as a therapeutic modality in severe chronic TBI.

Key words: Traumatic brain injury, autologous bone marrow mononuclear cells, cell transplantation, stem cells, PET CT, neurorehabilitation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Alok Sharma
Articles by Nandini Gokulchandran
Articles by Hemangi Sane
Articles by Pooja Kulkarni
Articles by Suhasini Pai
Articles by Khushboo Bhagwanani
Articles by Nayana Shet
Articles by Samson Nivins
Articles by Prerna Badhe
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Pai S, Bhagwanani K, Shet N, Nivins S, Badhe P. Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. Int J Med Rev Case Rep. 2019; 3(4): 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury

Web Style

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Pai S, Bhagwanani K, Shet N, Nivins S, Badhe P. Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. https://www.mdpub.net/?mno=284712 [Access: October 13, 2024]. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury

AMA (American Medical Association) Style

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Pai S, Bhagwanani K, Shet N, Nivins S, Badhe P. Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. Int J Med Rev Case Rep. 2019; 3(4): 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


Vancouver/ICMJE Style

Sharma A, Gokulchandran N, Sane H, Kulkarni P, Pai S, Bhagwanani K, Shet N, Nivins S, Badhe P. Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. Int J Med Rev Case Rep. (2019), [cited October 13, 2024]; 3(4): 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


Harvard Style

Sharma, A., Gokulchandran, . N., Sane, . H., Kulkarni, . P., Pai, . S., Bhagwanani, . K., Shet, . N., Nivins, . S. & Badhe, . P. (2019) Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. Int J Med Rev Case Rep, 3 (4), 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


Turabian Style

Sharma, Alok, Nandini Gokulchandran, Hemangi Sane, Pooja Kulkarni, Suhasini Pai, Khushboo Bhagwanani, Nayana Shet, Samson Nivins, and Prerna Badhe. 2019. Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. International Journal of Medical Reviews and Case Reports, 3 (4), 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


Chicago Style

Sharma, Alok, Nandini Gokulchandran, Hemangi Sane, Pooja Kulkarni, Suhasini Pai, Khushboo Bhagwanani, Nayana Shet, Samson Nivins, and Prerna Badhe. "Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury." International Journal of Medical Reviews and Case Reports 3 (2019), 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


MLA (The Modern Language Association) Style

Sharma, Alok, Nandini Gokulchandran, Hemangi Sane, Pooja Kulkarni, Suhasini Pai, Khushboo Bhagwanani, Nayana Shet, Samson Nivins, and Prerna Badhe. "Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury." International Journal of Medical Reviews and Case Reports 3.4 (2019), 131-135. Print. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


APA (American Psychological Association) Style

Sharma, A., Gokulchandran, . N., Sane, . H., Kulkarni, . P., Pai, . S., Bhagwanani, . K., Shet, . N., Nivins, . S. & Badhe, . P. (2019) Functional improvements monitored by Positron Emission Tomography imaging after cell transplantations in severe chronic Traumatic Brain Injury. International Journal of Medical Reviews and Case Reports, 3 (4), 131-135. doi:10.5455/IJMRCR.Positron-Emission-Tomography-severe-chronic-Traumatic-Brain-Injury


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500