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Case Report
Online Published: 10 Dec 2020
 


Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases

Vipal Parmar, Bhavna Mehta, Sandip Shah, Rahul Yadav, Mandava Rao.


Abstract
Leiomyosarcoma (LMS) of the colo-rectum is a rare malignant entity with unfavourable prognosis, and responds poorly to conventional chemo-radiation therapy. Only a few cases of the LMS of colorectum have so far been reported earlier. Here we report two such cases of primary leiomyosarcoma of sigmoid colon and rectum. Due to histological similarity with gastrointestinal stromal tumour (GIST), the LMS cases were misdiagnosed as GIST. This is essentially a pathological diagnosis having a similar histomorphological appearance that of GIST, but a different Immunohistochemistry profile, in contrast to GIST. Immunohistocytochemically LMS are negative for CD34, CD117 and DOG1 and positive for desmin as detected in this report. GIST is curable with surgery followed by imatinib (in intermediate /high-risk patients) while LMS behaves aggressively requiring radical excision of the tumour followed by intensive cytotoxic chemotherapy regimens. Thus it is important to diagnose LMS definitively by immunohistochemical profiling as the prognosis and treatment of these tumours vary from others as mentioned.

Key words: Leiomyosarcoma, colon, rectum, Immunohistochemistry, Rare case


 
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How to Cite this Article
Pubmed Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. 2021; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON

Web Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. https://www.mdpub.net/?mno=29416 [Access: October 13, 2024]. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON

AMA (American Medical Association) Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. 2021; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Vancouver/ICMJE Style

Parmar V, Mehta B, Shah S, Yadav R, Rao M. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep. (2021), [cited October 13, 2024]; 5(1): 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Harvard Style

Parmar, V., Mehta, . B., Shah, . S., Yadav, . R. & Rao, . M. (2021) Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. Int J Med Rev Case Rep, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Turabian Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. 2021. Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. International Journal of Medical Reviews and Case Reports, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


Chicago Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. "Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases." International Journal of Medical Reviews and Case Reports 5 (2021), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


MLA (The Modern Language Association) Style

Parmar, Vipal, Bhavna Mehta, Sandip Shah, Rahul Yadav, and Mandava Rao. "Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases." International Journal of Medical Reviews and Case Reports 5.1 (2021), 36-38. Print. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


APA (American Psychological Association) Style

Parmar, V., Mehta, . B., Shah, . S., Yadav, . R. & Rao, . M. (2021) Primary leiomyosarcoma of sigmoid colon and rectum – report of two cases. International Journal of Medical Reviews and Case Reports, 5 (1), 36-38. doi:10.5455/IJMRCR.PRIMARY-LEIOMYOSARCOMA-SIGMOID-COLON


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