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Online Publishing Date:
28 / 01 / 2022

 


Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis

Shaurya Pratap Singh, Priyanka Rai, Amarjot Singh, Sunil Kumar SIngh, Rohit Srivastava, Vaibhav Raj Gopal.


Abstract
Acute pancreatitis is a common and challenging disease that can develop both local and systemic complications. Most patients develop a mild and self-limited course; however, 10% to 20% of patients have a rapidly progressive inflammatory response associated with prolonged length of hospital stay and significant morbidity and mortality. The first four days are crucial in the evolution of acute pancreatitis, during which 15 to 25% of patients develop the severe form of disease3. Early aggressive and intensive treatment in the first phase can improve survival if one can predict the severity at an early stage
The aim of the study is to correlate APACHE-II scoring, C-Reactive Protein levels, Interleukin-6 estimation and Computed Tomography Severity Index in assessing the severity of acute pancreatitis.
Prospective Observational Comparative Pilot Study.
Statistical Analysis: Mcnamer tests were used to compare sensitivity and specificity of APACHE II scoring, CRP, IL 6 estimation and contrast-enhanced CT findings
Results: APACHE II at admission (p=0.004), at 72 hours (p<0.001), CT severity index (p<0.0001), serum interleukin level (p=0.0001) and Serum CRP levels (p=0.001) are statistically significant in predicting the severity of acute pancreatitis.
Conclusion: On comparing APACHE II, serum CRP, and IL-6, CTSI score at 72 hours it was seen that CTSI score had the best sensitivity, specificity, positive predictive value and negative predictive value. As CT is capable of defining the extent of local inflammation and the occurrence of local complications, it can be considered to be a more accurate marker of severity at 72 hours as compared to other prognostic indicators.

Key words: Acute Pancreatitis, APACHE-II, CRP, II-6 , Contrast CT score


 
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How to Cite this Article
Pubmed Style

Singh SP, Rai P, Singh A, SIngh SK, Srivastava R, Gopal VR. Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. Int J Med Rev Case Rep. 2022; 6(1): 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring

Web Style

Singh SP, Rai P, Singh A, SIngh SK, Srivastava R, Gopal VR. Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. https://www.mdpub.net/?mno=302645388 [Access: April 04, 2024]. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring

AMA (American Medical Association) Style

Singh SP, Rai P, Singh A, SIngh SK, Srivastava R, Gopal VR. Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. Int J Med Rev Case Rep. 2022; 6(1): 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


Vancouver/ICMJE Style

Singh SP, Rai P, Singh A, SIngh SK, Srivastava R, Gopal VR. Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. Int J Med Rev Case Rep. (2022), [cited April 04, 2024]; 6(1): 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


Harvard Style

Singh, S. P., Rai, . P., Singh, . A., SIngh, . S. K., Srivastava, . R. & Gopal, . V. R. (2022) Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. Int J Med Rev Case Rep, 6 (1), 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


Turabian Style

Singh, Shaurya Pratap, Priyanka Rai, Amarjot Singh, Sunil Kumar SIngh, Rohit Srivastava, and Vaibhav Raj Gopal. 2022. Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. International Journal of Medical Reviews and Case Reports, 6 (1), 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


Chicago Style

Singh, Shaurya Pratap, Priyanka Rai, Amarjot Singh, Sunil Kumar SIngh, Rohit Srivastava, and Vaibhav Raj Gopal. "Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis." International Journal of Medical Reviews and Case Reports 6 (2022), 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


MLA (The Modern Language Association) Style

Singh, Shaurya Pratap, Priyanka Rai, Amarjot Singh, Sunil Kumar SIngh, Rohit Srivastava, and Vaibhav Raj Gopal. "Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis." International Journal of Medical Reviews and Case Reports 6.1 (2022), 51-59. Print. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


APA (American Psychological Association) Style

Singh, S. P., Rai, . P., Singh, . A., SIngh, . S. K., Srivastava, . R. & Gopal, . V. R. (2022) Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis. International Journal of Medical Reviews and Case Reports, 6 (1), 51-59. doi:10.5455/IJMRCR.CorrelationOfAPACHE-IIScoring


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