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Original Research
Online Published: 23 Apr 2020
 


The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases

Safitri Ammarie, Hasyim Kasim, A M Luthfi Parewangi, Syakib Bakri, Haerani Rasyid, Arifin Seweng.


Abstract
Background: The mechanism that linked Non-Alcoholic Fatty Liver Diseases (NAFLD) and Chronic Kidney Diseases (CKD) is still difficult to determine what specific processes are underlying, but several studies have shown that NALFD and CKD have the same cardiometabolic and pathomechanical risk and this is related to an increase in inflammatory factors and homeostatic plasma, hyperuricemia, decreased insulin-like levels growth factor-1 (IGF-1), endothelial dysfunction and oxidative stress biomarkers
Methods: This was an observational study with a cross-sectional design. 130 Subject were man and woman aged from 18 – 60 years old with abdominal ultrasound result fatty liver in Wahidin Sudirohusodo hospital and Hasanuddin University Hospital, Makassar Indonesia.
Results: Among 130 subjects with NAFLD, mostly subject were man (56,9%), age 40-59 years old ( 51,6 %), obese ( 72,3%), Based on GFR the proportion of the subject mostly categorizes as Stage 1 CKD (GFR 90 ml/minutes/1,73m2) is 44, 6 % and liver fibrosis severity mostly categorizes as F0-F1 ( No fibrosis ) is 56,9 %. The proportion of higher GFR (CKD stage 1-2, GFR 60 – 90 ml/minutes/1,73m2 ) was found in the Non fibrosis group than in fibrosis group ( 77,0% vs 64,3 % p >0,005 ) and The proportion of Lower GFR (Stage 3-4 CKD, GFR 15-59 ml/minutes/1,73m2 ) was found higher in fibrosis than non-fibrosis ( 35,7% vs 23,0 % p > 0,005 ).
Conclusion: NAFLD Subject with severe liver fibrosis had lower eGFR.

Key words: liver fibrosis, nonalcoholic fatty liver diseases, glomerular filtration rate


 
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How to Cite this Article
Pubmed Style

Ammarie S, Kasim H, Parewangi AML, Bakri S, Rasyid H, Seweng A. The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. Int J Med Rev Case Rep. 2020; 4(5): 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY

Web Style

Ammarie S, Kasim H, Parewangi AML, Bakri S, Rasyid H, Seweng A. The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. https://www.mdpub.net/?mno=59597 [Access: April 02, 2025]. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY

AMA (American Medical Association) Style

Ammarie S, Kasim H, Parewangi AML, Bakri S, Rasyid H, Seweng A. The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. Int J Med Rev Case Rep. 2020; 4(5): 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


Vancouver/ICMJE Style

Ammarie S, Kasim H, Parewangi AML, Bakri S, Rasyid H, Seweng A. The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. Int J Med Rev Case Rep. (2020), [cited April 02, 2025]; 4(5): 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


Harvard Style

Ammarie, S., Kasim, . H., Parewangi, . A. M. L., Bakri, . S., Rasyid, . H. & Seweng, . A. (2020) The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. Int J Med Rev Case Rep, 4 (5), 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


Turabian Style

Ammarie, Safitri, Hasyim Kasim, A M Luthfi Parewangi, Syakib Bakri, Haerani Rasyid, and Arifin Seweng. 2020. The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. International Journal of Medical Reviews and Case Reports, 4 (5), 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


Chicago Style

Ammarie, Safitri, Hasyim Kasim, A M Luthfi Parewangi, Syakib Bakri, Haerani Rasyid, and Arifin Seweng. "The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases." International Journal of Medical Reviews and Case Reports 4 (2020), 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


MLA (The Modern Language Association) Style

Ammarie, Safitri, Hasyim Kasim, A M Luthfi Parewangi, Syakib Bakri, Haerani Rasyid, and Arifin Seweng. "The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases." International Journal of Medical Reviews and Case Reports 4.5 (2020), 6-10. Print. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


APA (American Psychological Association) Style

Ammarie, S., Kasim, . H., Parewangi, . A. M. L., Bakri, . S., Rasyid, . H. & Seweng, . A. (2020) The correlation of liver fibrosis severity with estimated glomerular filtration rate in non-alcoholic fatty liver diseases. International Journal of Medical Reviews and Case Reports, 4 (5), 6-10. doi:10.5455/IJMRCR.LIVER-FIBROSIS-SEVERITY


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