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Original Research
Online Published: 02 Feb 2022
 


Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro

Rawaa Mohammed Abdo, Sayran Kamal Mohammad Salih, Dian Jamel Salih, Asaad Abdulwahid Alasady.


Abstract
Aim: Sertraline is an active antidepressant drug that is being used in the treatment of psychiatric disorders for long-term use. The genotoxic effects of this drug. Sufficient studies reporting the genotoxic and carcinogenic effects of this drug have not been reported yet. This study aimed to assess the frequency of chromosomal aberrations on human lymphocytes in vitro.
Material and Methods: In this study, the in vitro genotoxic effects of Sertraline have been determined in human peripheral blood lymphocytes by using chromosomal aberrations: 5; 10; 25; 50.00; 75 and 100mg/mL concentrations of Sertraline were used. Sertraline significantly increased the frequency of chromosomal aberrations in high doses compared with the control. The two highest concentrations (75 and 100mg/mL) of Sertraline were significantly increased chromosomal aberrational s compared to recommended concentration (50mg/mL). A significantly higher frequency of chromosomal aberrations (p<0.05) was determined in treated cultures.
Conclusion: Sertraline is the genotoxic active ingredient in human lymphocytes in vitro. However, this genotoxic effect should be supported by in vivo studies.

Key words: Antidepressants, Sertraline, chromosomal aberrations, cytogenetics


 
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How to Cite this Article
Pubmed Style

Abdo RM, Salih SKM, Salih DJ, Alasady AA. Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. Int J Med Rev Case Rep. 2022; 6(3): 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug

Web Style

Abdo RM, Salih SKM, Salih DJ, Alasady AA. Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. https://www.mdpub.net/?mno=92249 [Access: October 13, 2024]. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug

AMA (American Medical Association) Style

Abdo RM, Salih SKM, Salih DJ, Alasady AA. Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. Int J Med Rev Case Rep. 2022; 6(3): 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


Vancouver/ICMJE Style

Abdo RM, Salih SKM, Salih DJ, Alasady AA. Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. Int J Med Rev Case Rep. (2022), [cited October 13, 2024]; 6(3): 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


Harvard Style

Abdo, R. M., Salih, . S. K. M., Salih, . D. J. & Alasady, . A. A. (2022) Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. Int J Med Rev Case Rep, 6 (3), 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


Turabian Style

Abdo, Rawaa Mohammed, Sayran Kamal Mohammad Salih, Dian Jamel Salih, and Asaad Abdulwahid Alasady. 2022. Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. International Journal of Medical Reviews and Case Reports, 6 (3), 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


Chicago Style

Abdo, Rawaa Mohammed, Sayran Kamal Mohammad Salih, Dian Jamel Salih, and Asaad Abdulwahid Alasady. "Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro." International Journal of Medical Reviews and Case Reports 6 (2022), 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


MLA (The Modern Language Association) Style

Abdo, Rawaa Mohammed, Sayran Kamal Mohammad Salih, Dian Jamel Salih, and Asaad Abdulwahid Alasady. "Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro." International Journal of Medical Reviews and Case Reports 6.3 (2022), 34-39. Print. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


APA (American Psychological Association) Style

Abdo, R. M., Salih, . S. K. M., Salih, . D. J. & Alasady, . A. A. (2022) Cytogenetic evaluation of antidepressant drug, Sertraline, in vitro. International Journal of Medical Reviews and Case Reports, 6 (3), 34-39. doi:10.5455/IJMRCR.Cytogeneticevaluationofantidepressantdrug


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