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Original Research
Online Published: 14 Nov 2022
 


The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.

Utkarsh Patel, Mahendra Thakre, Dnyaneshwar Asole, P.p. Ashok.


Abstract
TITLE: The Utility of Plasma N- Terminal Brain Natriuretic Peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.
PURPOSE: To measure plasma NT-Pro BNP in patients with acute ischemic stroke and investigate whether the plasma NT- pro BNP level can be a useful bio marker to differentiate cardio embolic (CE) stroke from non-cardio embolic (NCE) stroke or not.
STUDY DESIGN: In our analytic observational prospective study, 66 patients were enrolled within 24 hours of the onset of acute ischemic stroke and met inclusion and exclusion criteria.
METHODOLOGY: Plasma NT-pro BNP level was performed in each patient. Clinical observations were recorded on special performa designed for the study. They were classified in to four groups: Cardioembolic (CE), Large artery atherosclerosis (LAA), Small-vessel disease (SVD) and other subtypes according to TOAST classification. Study outcome was measured by applying appropriate statistical tests at the end of all patient enrolments.
RESULTS: Out of 66 patients, 21(31.81 %) were cardioembolic whereas 45 (68.18%) patients were in non-cardioembolic (NCE) group. The result showed that plasma NT pro BNP levels were significantly higher in CE group than NCE group (p value<0.001). The optimal cut off point for NT pro BNP levels to differentiate CE stroke from NCE stroke was > 594 pg./ml with 93.33% Specificity and 66.67% Sensitivity.
CONCLUSION: As plasma biomarker NT-pro BNP has a good sensitivity, specificity and accuracy for early identification of cardio embolic stroke.

Key words: Plasma biomarker, NT-pro BNP, Cardio embolic Stroke


 
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How to Cite this Article
Pubmed Style

Patel U, Thakre M, Asole D, Ashok P. The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. Int J Med Rev Case Rep. 2022; 6(21): 18-24. doi:10.5455/IJMRCR.172-1661420740

Web Style

Patel U, Thakre M, Asole D, Ashok P. The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. https://www.mdpub.net/?mno=109086 [Access: April 02, 2025]. doi:10.5455/IJMRCR.172-1661420740

AMA (American Medical Association) Style

Patel U, Thakre M, Asole D, Ashok P. The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. Int J Med Rev Case Rep. 2022; 6(21): 18-24. doi:10.5455/IJMRCR.172-1661420740


Vancouver/ICMJE Style

Patel U, Thakre M, Asole D, Ashok P. The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. Int J Med Rev Case Rep. (2022), [cited April 02, 2025]; 6(21): 18-24. doi:10.5455/IJMRCR.172-1661420740


Harvard Style

Patel, U., Thakre, . M., Asole, . D. & Ashok, . P. (2022) The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. Int J Med Rev Case Rep, 6 (21), 18-24. doi:10.5455/IJMRCR.172-1661420740


Turabian Style

Patel, Utkarsh, Mahendra Thakre, Dnyaneshwar Asole, and P.p. Ashok. 2022. The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. International Journal of Medical Reviews and Case Reports, 6 (21), 18-24. doi:10.5455/IJMRCR.172-1661420740


Chicago Style

Patel, Utkarsh, Mahendra Thakre, Dnyaneshwar Asole, and P.p. Ashok. "The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.." International Journal of Medical Reviews and Case Reports 6 (2022), 18-24. doi:10.5455/IJMRCR.172-1661420740


MLA (The Modern Language Association) Style

Patel, Utkarsh, Mahendra Thakre, Dnyaneshwar Asole, and P.p. Ashok. "The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.." International Journal of Medical Reviews and Case Reports 6.21 (2022), 18-24. Print. doi:10.5455/IJMRCR.172-1661420740


APA (American Psychological Association) Style

Patel, U., Thakre, . M., Asole, . D. & Ashok, . P. (2022) The Utility of Plasma N- Terminal Brain Natriuretic peptide (NT- Pro BNP) as a Biomarker to Differentiate Cardio embolic Stroke from Non-Cardio embolic Stroke.. International Journal of Medical Reviews and Case Reports, 6 (21), 18-24. doi:10.5455/IJMRCR.172-1661420740


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