E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 12
7 / 12Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Review Article
Online Published: 05 Feb 2023
 


Vitamin D Deficiency: A Potential Factor Behind Depression

Archana Nimesh, Aparna Das, Thoraya Mohamed Elhassan A-elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali Alshaikh, Sathishbabu Murugaiyan.


Abstract
Depression, a leading cause of disability affecting around 264 million people globally has multifactorial causes like psychosocial, biological, genetic and hormonal. Vitamin D, a neuroactive steroid easily crosses blood brain barrier and has widespread receptors in the brain tissue suggesting that vitamin D could have a role in the brain functioning. This paper reviews if vitamin D deficiency is associated with depression and the possible biochemical mechanisms for explaining the same. For this review, scientific studies published till December 2021 were searched on PubMed, Google Scholar and Google using keywords, vitamin D, vitamin D deficiency, depression, mechanisms, association and supplementation. Studies have found that vitamin D is important for expression of neurotransmitters, neuroimmunomodulation and antioxidant production. Neurotrophic hypothesis and monoamine neurotransmission hypothesis explains the biochemical mechanisms behind depression. Many studies found insufficient vitamin D levels being associated with depression and the symptoms improved upon vitamin D supplementation. Thus, it is recommended that serum vitamin D in depression patients should be monitored and normalized if found deficient. Vitamin D supplementation as an adjuvant therapy to standard antidepressants therapy could be more effective to treat depression not responding to standalone vitamin D supplementation. Vitamin D may be used to treat depression especially in patients with poor compliance to antidepressant drugs.

Key words: vitamin D, vitamin D deficiency, depression, mechanism, association, vitamin D supplementation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Archana Nimesh
Articles by Aparna Das
Articles by Thoraya Mohamed Elhassan A-Elgadir
Articles by Rishi Kumar Bharti
Articles by Rehan Monir
Articles by Ayoub Ali AlShaikh
Articles by Sathishbabu Murugaiyan
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Nimesh A, Das A, A-elgadir TME, Bharti RK, Monir R, Alshaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. 2022; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386

Web Style

Nimesh A, Das A, A-elgadir TME, Bharti RK, Monir R, Alshaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. https://www.mdpub.net/?mno=13956 [Access: April 02, 2025]. doi:10.5455/IJMRCR.172-1649779386

AMA (American Medical Association) Style

Nimesh A, Das A, A-elgadir TME, Bharti RK, Monir R, Alshaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. 2022; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386


Vancouver/ICMJE Style

Nimesh A, Das A, A-elgadir TME, Bharti RK, Monir R, Alshaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. (2022), [cited April 02, 2025]; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386


Harvard Style

Nimesh, A., Das, . A., A-elgadir, . T. M. E., Bharti, . R. K., Monir, . R., Alshaikh, . A. A. & Murugaiyan, . S. (2022) Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


Turabian Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali Alshaikh, and Sathishbabu Murugaiyan. 2022. Vitamin D Deficiency: A Potential Factor Behind Depression. International Journal of Medical Reviews and Case Reports, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


Chicago Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali Alshaikh, and Sathishbabu Murugaiyan. "Vitamin D Deficiency: A Potential Factor Behind Depression." International Journal of Medical Reviews and Case Reports 6 (2022), 25-30. doi:10.5455/IJMRCR.172-1649779386


MLA (The Modern Language Association) Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali Alshaikh, and Sathishbabu Murugaiyan. "Vitamin D Deficiency: A Potential Factor Behind Depression." International Journal of Medical Reviews and Case Reports 6.21 (2022), 25-30. Print. doi:10.5455/IJMRCR.172-1649779386


APA (American Psychological Association) Style

Nimesh, A., Das, . A., A-elgadir, . T. M. E., Bharti, . R. K., Monir, . R., Alshaikh, . A. A. & Murugaiyan, . S. (2022) Vitamin D Deficiency: A Potential Factor Behind Depression. International Journal of Medical Reviews and Case Reports, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500