E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 11
7 / 11Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Review Article
Online Published: 30 Aug 2018
 


THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN

Pascanus LP Togatorop, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma.


Abstract
Neuropathic pain (NP) is a pain caused by lesions in the nervous system. Several causes of NP are traumatic, metabolic disorders, ischemia, toxins, infections, immune-related, and hereditary. The pathophysiology of NP is very complicated and unknown entirely. Therefore the treatment of NP is still unsatisfactory. Recent studies believed the critical role of primary inflammatory mediators in the pathophysiology of NP especially leukotrienes (LTs). The 5-lipoxygenase enzyme (5-LOX) is an enzyme that plays a role in the metabolism of arachidonic acid into LTs. Leukotrienes (LTs) are the essential inflammatory mediators in the pathophysiology of NP. Leukotriene B4 (LTB4) can cause chemotaxis on neutrophils, lowering nociceptors threshold and may contribute to NP. Several studies believed the administration of 5-LOX inhibitors or LTs receptor antagonists could be useful in the management of NP. The purpose of this review is to summarize the involvement of 5-LOX enzyme as an essential role in the pathophysiology and management of NP.

Key words: 5-lipoxygenase, leukotrienes, pathophysiology of neuropathic pain, inflammatory mediators, management of neuropathic pain


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Pascanus LP Togatorop
Articles by Faldi Yaputra
Articles by Jimmy FA Barus
Articles by I Putu Eka Widyadharma
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

Web Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. https://www.mdpub.net/?mno=2428 [Access: October 13, 2024]. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN

AMA (American Medical Association) Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. 2018; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Vancouver/ICMJE Style

Togatorop PL, Yaputra F, Barus JF, Widyadharma IPE, . THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep. (2018), [cited October 13, 2024]; 2(3): 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Harvard Style

Togatorop, P. L., Yaputra, F. ., Barus, J. F., Widyadharma, I. P. . E. & (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. Int J Med Rev Case Rep, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Turabian Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . 2018. THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Chicago Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2 (2018), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


MLA (The Modern Language Association) Style

Togatorop, Pascanus LP, Faldi Yaputra, Jimmy FA Barus, I Putu Eka Widyadharma, and . "THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN." International Journal of Medical Reviews and Case Reports 2.3 (2018), 58-61. Print. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


APA (American Psychological Association) Style

Togatorop, P. L., Yaputra, F. ., Barus, J. F., Widyadharma, I. P. . E. & (2018) THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN. International Journal of Medical Reviews and Case Reports, 2 (3), 58-61. doi:10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500