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Review Article
Online Published: 17 Jun 2018
 


Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review

Leonardo Wiranata Soesilopranoto, Yesyurun Sekundus Torrys, Randy Martianus, Tjokorda Istri Pramitasuri, Ida Ayu Sri Wijayanti, I Putu Eka Widyadharma.


Abstract
ALS is one of the neurodegenerative diseases that have high morbidity and mortality. Beside difficulties to manage, it also has a limited diagnostic method to detect ALS in early onset. Neurofilament Light Chain (NFL) is a component of cerebrospinal fluid (CSF) which regulate axon diameter calibration and conduction speed in action potential of neurons. In this review, several literatures were evaluated and selected. The NFL measurement with ECL method has high sensitivity and specificity, that makes this method reliable to use in the diagnosis of ALS.

Key words: Neurofilament Light Chain, Electrochemiluminescence, Amyotrophic lateral sclerosis, Diagnostic


 
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How to Cite this Article
Pubmed Style

Soesilopranoto LW, Torrys YS, Martianus R, Pramitasuri TI, Wijayanti IAS, Widyadharma IPE. Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. Int J Med Rev Case Rep. 2018; 2(3): 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis

Web Style

Soesilopranoto LW, Torrys YS, Martianus R, Pramitasuri TI, Wijayanti IAS, Widyadharma IPE. Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. https://www.mdpub.net/?mno=300480 [Access: April 02, 2025]. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis

AMA (American Medical Association) Style

Soesilopranoto LW, Torrys YS, Martianus R, Pramitasuri TI, Wijayanti IAS, Widyadharma IPE. Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. Int J Med Rev Case Rep. 2018; 2(3): 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


Vancouver/ICMJE Style

Soesilopranoto LW, Torrys YS, Martianus R, Pramitasuri TI, Wijayanti IAS, Widyadharma IPE. Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. Int J Med Rev Case Rep. (2018), [cited April 02, 2025]; 2(3): 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


Harvard Style

Soesilopranoto, L. W., Torrys, . Y. S., Martianus, . R., Pramitasuri, . T. I., Wijayanti, . I. A. S. & Widyadharma, . I. P. E. (2018) Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. Int J Med Rev Case Rep, 2 (3), 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


Turabian Style

Soesilopranoto, Leonardo Wiranata, Yesyurun Sekundus Torrys, Randy Martianus, Tjokorda Istri Pramitasuri, Ida Ayu Sri Wijayanti, and I Putu Eka Widyadharma. 2018. Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. International Journal of Medical Reviews and Case Reports, 2 (3), 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


Chicago Style

Soesilopranoto, Leonardo Wiranata, Yesyurun Sekundus Torrys, Randy Martianus, Tjokorda Istri Pramitasuri, Ida Ayu Sri Wijayanti, and I Putu Eka Widyadharma. "Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review." International Journal of Medical Reviews and Case Reports 2 (2018), 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


MLA (The Modern Language Association) Style

Soesilopranoto, Leonardo Wiranata, Yesyurun Sekundus Torrys, Randy Martianus, Tjokorda Istri Pramitasuri, Ida Ayu Sri Wijayanti, and I Putu Eka Widyadharma. "Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review." International Journal of Medical Reviews and Case Reports 2.3 (2018), 53-57. Print. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


APA (American Psychological Association) Style

Soesilopranoto, L. W., Torrys, . Y. S., Martianus, . R., Pramitasuri, . T. I., Wijayanti, . I. A. S. & Widyadharma, . I. P. E. (2018) Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review. International Journal of Medical Reviews and Case Reports, 2 (3), 53-57. doi:10.5455/IJMRCR.nfl-ecl-amyotrophic-lateral-sclerosis


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